(098) ERβ Polymorphism (rs1256049; 1082G>A) Association with Male Infertility: A Meta-analysis

Abstract Introduction In men, estrogen is produced in the testis by Sertoli cell, Leydig cell and germ cells that play an important role maturation capacitation of sperms. The action mediated two specific Receptors: Estrogen receptors α (ESRα) receptor β (ESRβ). polymorphisms ERβ gene confer a lower sex hormone binding globulin (SHBG) thus stronger unbound effect, which may adversely affect human spermatogenesis. SHBG involved both delivering reproductive hormones to target tissues controlling concentration androgens estrogens serum tissues. Two silent G/A ER□ genes i.e., rs1256049 rs4986938 have been demonstrated. polymorphism studied at 1082G>A presented contrary results. Objective study aims demonstrate prevalence Receptor Beta (ERβ) (1082G>A; rs1256049) ethnicities Asian Caucasian, its association with risk male infertility. Methods databases PUBMED NCBI were searched retrieve case-control studies, published from 2005 date, regarding infertility selected for this meta-analysis. Results A total 10 studies out 85articles (6 + 4 Caucasian), including 1613 cases 1654 controls, determiningERβ met inclusion criteria. Significant (p<0.05) was found between on basis all four genetic models i.e. Allelic model (A vs G: OR= 1.19, 95% CI [1.00-1.43], I2 = 62%), additive (AA GG: 0.54, [0.31-0.94], 0%), dominant (AA+AG 1.37, [1.11-1.69], 52%) recessive AG+GG: 0.55, [0.32-0.96], 0%). case Caucasian population, significantly associated allelic 2.10, [1.31-3.36], 37%) as well 2.70, [1.62-4.51], 72%), whereas it had significant [0.31-0.96], 0%) only. Conclusions (rs1256049 1082G>A) linked higher has more severe effect population than population. Disclosure No